| Friday, January 1st, 2010 |
| Drafted 1B F. Thomas in the 2010 inaugural draft (Round 1, Pick 4, 4th overall Pick). |
| Drafted 2B H. Trosky in the 2010 inaugural draft (Round 2, Pick 27, 57th overall Pick). |
| Drafted CF S. Musial in the 2010 inaugural draft (Round 3, Pick 4, 64th overall Pick). |
| Drafted SP E. Cicotte in the 2010 inaugural draft (Round 4, Pick 27, 117th overall Pick). |
| Drafted SP W. Bell in the 2010 inaugural draft (Round 5, Pick 4, 124th overall Pick). |
| Drafted SP J. Clarkson in the 2010 inaugural draft (Round 6, Pick 27, 177th overall Pick). |
| Drafted SP W. Foster in the 2010 inaugural draft (Round 7, Pick 4, 184th overall Pick). |
| Drafted MR S. Rowe in the 2010 inaugural draft (Round 8, Pick 27, 237th overall Pick). |
| Drafted 3B P. Molitor in the 2010 inaugural draft (Round 9, Pick 4, 244th overall Pick). |
| Drafted SS E. Banks in the 2010 inaugural draft (Round 10, Pick 27, 297th overall Pick). |
| Drafted C C. Hoiles in the 2010 inaugural draft (Round 11, Pick 4, 304th overall Pick). |
| Drafted LF W. Berger in the 2010 inaugural draft (Round 12, Pick 27, 357th overall Pick). |
| Drafted MR R. Prim in the 2010 inaugural draft (Round 13, Pick 4, 364th overall Pick). |
| Drafted SP M. Drabowsky in the 2010 inaugural draft (Round 14, Pick 27, 417th overall Pick). |
| Drafted MR J. Marichal in the 2010 inaugural draft (Round 15, Pick 4, 424th overall Pick). |
| Drafted MR A. Demaree in the 2010 inaugural draft (Round 16, Pick 27, 477th overall Pick). |
| Drafted MR M. Marshall in the 2010 inaugural draft (Round 17, Pick 4, 484th overall Pick). |
| Drafted C B. Phelps in the 2010 inaugural draft (Round 18, Pick 27, 537th overall Pick). |
| Drafted RF T. Salmon in the 2010 inaugural draft (Round 19, Pick 4, 544th overall Pick). |
| Drafted RF S. Lezcano in the 2010 inaugural draft (Round 20, Pick 27, 597th overall Pick). |
| Drafted 1B M. Vaughn in the 2010 inaugural draft (Round 21, Pick 4, 604th overall Pick). |
| Drafted 1B W. Dropo in the 2010 inaugural draft (Round 22, Pick 27, 657th overall Pick). |
| Drafted LF H. Manush in the 2010 inaugural draft (Round 23, Pick 4, 664th overall Pick). |
| Drafted SP D. Roberts in the 2010 inaugural draft (Round 24, Pick 27, 717th overall Pick). |
| Drafted SP J. Bagby in the 2010 inaugural draft (Round 25, Pick 4, 724th overall Pick). |
| Drafted SP R. Aguilera in the 2010 inaugural draft (Round 26, Pick 27, 777th overall Pick). |
| Drafted SS W. Wells in the 2010 inaugural draft (Round 27, Pick 4, 784th overall Pick). |
| Drafted MR C. Fraser in the 2010 inaugural draft (Round 28, Pick 27, 837th overall Pick). |
| Drafted C W. Cooper in the 2010 inaugural draft (Round 29, Pick 4, 844th overall Pick). |
| Drafted LF G. Woodling in the 2010 inaugural draft (Round 30, Pick 27, 897th overall Pick). |
| Drafted CF E. Roush in the 2010 inaugural draft (Round 31, Pick 4, 904th overall Pick). |
| Drafted SP B. Lemon in the 2010 inaugural draft (Round 32, Pick 27, 957th overall Pick). |
| Drafted 2B F. Vina in the 2010 inaugural draft (Round 33, Pick 4, 964th overall Pick). |
| Drafted RF R. Cullenbine in the 2010 inaugural draft (Round 34, Pick 27, 1017th overall Pick). |
| Drafted MR B. Rogan in the 2010 inaugural draft (Round 35, Pick 4, 1024th overall Pick). |
| Drafted SP T. Larkin in the 2010 inaugural draft (Round 36, Pick 27, 1077th overall Pick). |
| Drafted MR D. Taylor in the 2010 inaugural draft (Round 37, Pick 4, 1084th overall Pick). |
| Drafted 3B D. Prothro in the 2010 inaugural draft (Round 38, Pick 27, 1137th overall Pick). |
| Drafted CL H. Wilhelm in the 2010 inaugural draft (Round 39, Pick 4, 1144th overall Pick). |
| Drafted 1B A. Oliver in the 2010 inaugural draft (Round 40, Pick 27, 1197th overall Pick). |
| Drafted 1B J. Judge in the 2010 inaugural draft (Round 41, Pick 4, 1204th overall Pick). |
