| Friday, January 1st, 2010 |
| Drafted RF J. Jackson in the 2010 inaugural draft (Round 1, Pick 10, 10th overall Pick). |
| Drafted 2B H. Trosky in the 2010 inaugural draft (Round 2, Pick 21, 51st overall Pick). |
| Drafted C J. Bench in the 2010 inaugural draft (Round 3, Pick 10, 70th overall Pick). |
| Drafted SP J. Devlin in the 2010 inaugural draft (Round 4, Pick 21, 111st overall Pick). |
| Drafted SP L. Corcoran in the 2010 inaugural draft (Round 5, Pick 10, 130th overall Pick). |
| Drafted MR T. Mullane in the 2010 inaugural draft (Round 6, Pick 21, 171st overall Pick). |
| Drafted SP F. Goldsmith in the 2010 inaugural draft (Round 7, Pick 10, 190th overall Pick). |
| Drafted 3B P. Molitor in the 2010 inaugural draft (Round 8, Pick 21, 231st overall Pick). |
| Drafted 1B K. Mitchell in the 2010 inaugural draft (Round 9, Pick 10, 250th overall Pick). |
| Drafted SP E. Summers in the 2010 inaugural draft (Round 10, Pick 21, 291st overall Pick). |
| Drafted LF T. Francona in the 2010 inaugural draft (Round 11, Pick 10, 310th overall Pick). |
| Drafted MR P. Ragan in the 2010 inaugural draft (Round 12, Pick 21, 351st overall Pick). |
| Drafted SP B. Burns in the 2010 inaugural draft (Round 13, Pick 10, 370th overall Pick). |
| Drafted MR W. Ford in the 2010 inaugural draft (Round 14, Pick 21, 411st overall Pick). |
| Drafted MR A. Demaree in the 2010 inaugural draft (Round 15, Pick 10, 430th overall Pick). |
| Drafted SS J. Reilly in the 2010 inaugural draft (Round 16, Pick 21, 471st overall Pick). |
| Drafted CF S. Chapman in the 2010 inaugural draft (Round 17, Pick 10, 490th overall Pick). |
| Drafted CL D. Corbett in the 2010 inaugural draft (Round 18, Pick 21, 531st overall Pick). |
| Drafted C J. Gooch in the 2010 inaugural draft (Round 19, Pick 10, 550th overall Pick). |
| Drafted LF G. Hall in the 2010 inaugural draft (Round 20, Pick 21, 591st overall Pick). |
| Drafted CF C. Seymour in the 2010 inaugural draft (Round 21, Pick 10, 610th overall Pick). |
| Drafted 1B R. York in the 2010 inaugural draft (Round 22, Pick 21, 651st overall Pick). |
| Drafted RF B. McGowan in the 2010 inaugural draft (Round 23, Pick 10, 670th overall Pick). |
| Drafted 1B K. Hernandez in the 2010 inaugural draft (Round 24, Pick 21, 711st overall Pick). |
| Drafted SP H. Ehmke in the 2010 inaugural draft (Round 25, Pick 10, 730th overall Pick). |
| Drafted CF B. Williams in the 2010 inaugural draft (Round 26, Pick 21, 771st overall Pick). |
| Drafted RF I. Boone in the 2010 inaugural draft (Round 27, Pick 10, 790th overall Pick). |
| Drafted SP R. Aguilera in the 2010 inaugural draft (Round 28, Pick 21, 831st overall Pick). |
| Drafted 1B A. Galarraga in the 2010 inaugural draft (Round 29, Pick 10, 850th overall Pick). |
| Drafted SS H. Richardson in the 2010 inaugural draft (Round 30, Pick 21, 891st overall Pick). |
| Drafted LF W. Horton in the 2010 inaugural draft (Round 31, Pick 10, 910th overall Pick). |
| Drafted SP G. Jackson in the 2010 inaugural draft (Round 32, Pick 21, 951st overall Pick). |
| Drafted C H. Severeid in the 2010 inaugural draft (Round 33, Pick 10, 970th overall Pick). |
| Drafted MR C. Hodnett in the 2010 inaugural draft (Round 34, Pick 21, 1011st overall Pick). |
| Drafted 2B C. Biggio in the 2010 inaugural draft (Round 35, Pick 10, 1030th overall Pick). |
| Drafted 3B E. Yost in the 2010 inaugural draft (Round 36, Pick 21, 1071st overall Pick). |
| Drafted SP M. Harder in the 2010 inaugural draft (Round 37, Pick 10, 1090th overall Pick). |
| Drafted SP J. Denny in the 2010 inaugural draft (Round 38, Pick 21, 1131st overall Pick). |
| Drafted CL M. Jackson in the 2010 inaugural draft (Round 39, Pick 10, 1150th overall Pick). |
| Drafted SS T. Foli in the 2010 inaugural draft (Round 40, Pick 21, 1191st overall Pick). |
| Drafted 2B G. Cutshaw in the 2010 inaugural draft (Round 41, Pick 10, 1210th overall Pick). |
| Purchased the contract of SP R. Aguilera from Triple A Indianapolis. |
| Purchased the contract of SP G. Jackson from Triple A Indianapolis. |
| Purchased the contract of SP J. Denny from Triple A Indianapolis. |
| Purchased the contract of C H. Severeid from Triple A Indianapolis. |
| Purchased the contract of 3B H. Richardson from Triple A Indianapolis. |
| Purchased the contract of 1B A. Galarraga from Triple A Indianapolis. |
| Demoted SP H. Ehmke to Triple A Indianapolis. |
| Demoted CL D. Corbett to Triple A Indianapolis. |
| Demoted C J. Gooch to Triple A Indianapolis. |
| Demoted 1B R. York to Triple A Indianapolis. |
| Demoted CF S. Chapman to Triple A Indianapolis. |
| Demoted 1B K. Hernandez to Triple A Indianapolis. |
| Demoted SS T. Foli from Triple A Indianapolis to Double A Columbus. |
