| Friday, January 1st, 2010 |
| Drafted SS J. Beckwith in the 2010 inaugural draft (Round 1, Pick 4, 4th overall Pick). |
| Drafted 1B J. Olerud in the 2010 inaugural draft (Round 2, Pick 27, 57th overall Pick). |
| Drafted RF H. Baines in the 2010 inaugural draft (Round 3, Pick 4, 64th overall Pick). |
| Drafted SP T. McGraw in the 2010 inaugural draft (Round 4, Pick 27, 117th overall Pick). |
| Drafted SP H. Krause in the 2010 inaugural draft (Round 5, Pick 4, 124th overall Pick). |
| Drafted LF A. Belle in the 2010 inaugural draft (Round 6, Pick 27, 177th overall Pick). |
| Drafted SP B. Caruthers in the 2010 inaugural draft (Round 7, Pick 4, 184th overall Pick). |
| Drafted CL D. Eckersley in the 2010 inaugural draft (Round 8, Pick 27, 237th overall Pick). |
| Drafted SP H. Berger in the 2010 inaugural draft (Round 9, Pick 4, 244th overall Pick). |
| Drafted C J. Milligan in the 2010 inaugural draft (Round 10, Pick 27, 297th overall Pick). |
| Drafted CF D. Snider in the 2010 inaugural draft (Round 11, Pick 4, 304th overall Pick). |
| Drafted MR R. Patterson in the 2010 inaugural draft (Round 12, Pick 27, 357th overall Pick). |
| Drafted 2B E. Collins in the 2010 inaugural draft (Round 13, Pick 4, 364th overall Pick). |
| Drafted MR R. Wolff in the 2010 inaugural draft (Round 14, Pick 27, 417th overall Pick). |
| Drafted 3B B. Elliott in the 2010 inaugural draft (Round 15, Pick 4, 424th overall Pick). |
| Drafted SP R. Foster in the 2010 inaugural draft (Round 16, Pick 27, 477th overall Pick). |
| Drafted MR J. Pizarro in the 2010 inaugural draft (Round 17, Pick 4, 484th overall Pick). |
| Drafted C J. Grim in the 2010 inaugural draft (Round 18, Pick 27, 537th overall Pick). |
| Drafted MR J. Acker in the 2010 inaugural draft (Round 19, Pick 4, 544th overall Pick). |
| Drafted 1B T. Kluszewski in the 2010 inaugural draft (Round 20, Pick 27, 597th overall Pick). |
| Drafted SS E. Banks in the 2010 inaugural draft (Round 21, Pick 4, 604th overall Pick). |
| Drafted 3B J. Torre in the 2010 inaugural draft (Round 22, Pick 27, 657th overall Pick). |
| Drafted RF F. Jones in the 2010 inaugural draft (Round 23, Pick 4, 664th overall Pick). |
| Drafted RF J. Wolf in the 2010 inaugural draft (Round 24, Pick 27, 717th overall Pick). |
| Drafted SP B. Byrd in the 2010 inaugural draft (Round 25, Pick 4, 724th overall Pick). |
| Drafted CF F. Bordagaray in the 2010 inaugural draft (Round 26, Pick 27, 777th overall Pick). |
| Drafted 2B R. Peckinpaugh in the 2010 inaugural draft (Round 27, Pick 4, 784th overall Pick). |
| Drafted LF J. Barrett in the 2010 inaugural draft (Round 28, Pick 27, 837th overall Pick). |
| Drafted RF C. Williams in the 2010 inaugural draft (Round 29, Pick 4, 844th overall Pick). |
| Drafted SS D. Pratt in the 2010 inaugural draft (Round 30, Pick 27, 897th overall Pick). |
| Drafted SP J. Koosman in the 2010 inaugural draft (Round 31, Pick 4, 904th overall Pick). |
| Drafted 3B B. Dillinger in the 2010 inaugural draft (Round 32, Pick 27, 957th overall Pick). |
| Drafted C V. Clemons in the 2010 inaugural draft (Round 33, Pick 4, 964th overall Pick). |
| Drafted MR B. Reynolds in the 2010 inaugural draft (Round 34, Pick 27, 1017th overall Pick). |
| Drafted SP F. Bradley in the 2010 inaugural draft (Round 35, Pick 4, 1024th overall Pick). |
| Drafted 1B F. Fain in the 2010 inaugural draft (Round 36, Pick 27, 1077th overall Pick). |
| Drafted SP A. Henderson in the 2010 inaugural draft (Round 37, Pick 4, 1084th overall Pick). |
| Drafted SP B. O'Brien in the 2010 inaugural draft (Round 38, Pick 27, 1137th overall Pick). |
| Drafted CL K. Foulke in the 2010 inaugural draft (Round 39, Pick 4, 1144th overall Pick). |
| Drafted RF S. Rice in the 2010 inaugural draft (Round 40, Pick 27, 1197th overall Pick). |
| Drafted 1B E. Cartwright in the 2010 inaugural draft (Round 41, Pick 4, 1204th overall Pick). |
| Purchased the contract of MR B. Reynolds from Triple A Dearborn Heights. |
| Purchased the contract of SP J. Koosman from Triple A Dearborn Heights. |
| Purchased the contract of RF C. Williams from Triple A Dearborn Heights. |
| Demoted SP B. Byrd to Triple A Dearborn Heights. |
| Demoted C J. Grim to Triple A Dearborn Heights. |
| Demoted RF F. Jones to Triple A Dearborn Heights. |
| Demoted SP B. O'Brien from Triple A Dearborn Heights to Double A Annapolis. |
