| Friday, January 1st, 2010 |
| Drafted C L. Santop in the 2010 inaugural draft (Round 1, Pick 1, 1st overall Pick). |
| Drafted RF T. McCreery in the 2010 inaugural draft (Round 2, Pick 30, 60th overall Pick). |
| Drafted 1B N. Cash in the 2010 inaugural draft (Round 3, Pick 1, 61st overall Pick). |
| Drafted SP J. Whitney in the 2010 inaugural draft (Round 4, Pick 30, 120th overall Pick). |
| Drafted SP W. Foster in the 2010 inaugural draft (Round 5, Pick 1, 121st overall Pick). |
| Drafted MR E. Smith in the 2010 inaugural draft (Round 6, Pick 30, 180th overall Pick). |
| Drafted 2B L. Doyle in the 2010 inaugural draft (Round 7, Pick 1, 181st overall Pick). |
| Drafted SP N. Callahan in the 2010 inaugural draft (Round 8, Pick 30, 240th overall Pick). |
| Drafted CF P. Hill in the 2010 inaugural draft (Round 9, Pick 1, 241st overall Pick). |
| Drafted SS O. Burns in the 2010 inaugural draft (Round 10, Pick 30, 300th overall Pick). |
| Drafted LF R. Kiner in the 2010 inaugural draft (Round 11, Pick 1, 301st overall Pick). |
| Drafted CL J. Pfeffer in the 2010 inaugural draft (Round 12, Pick 30, 360th overall Pick). |
| Drafted MR H. Vaughn in the 2010 inaugural draft (Round 13, Pick 1, 361st overall Pick). |
| Drafted 3B C. Travis in the 2010 inaugural draft (Round 14, Pick 30, 420th overall Pick). |
| Drafted MR J. Orosco in the 2010 inaugural draft (Round 15, Pick 1, 421st overall Pick). |
| Drafted MR B. Ojeda in the 2010 inaugural draft (Round 16, Pick 30, 480th overall Pick). |
| Drafted SP J. Weyhing in the 2010 inaugural draft (Round 17, Pick 1, 481st overall Pick). |
| Drafted SP P. Splittorff in the 2010 inaugural draft (Round 18, Pick 30, 540th overall Pick). |
| Drafted C T. Simmons in the 2010 inaugural draft (Round 19, Pick 1, 541st overall Pick). |
| Drafted 1B J. Fournier in the 2010 inaugural draft (Round 20, Pick 30, 600th overall Pick). |
| Drafted 1B R. Carew in the 2010 inaugural draft (Round 21, Pick 1, 601st overall Pick). |
| Drafted 1B W. Dropo in the 2010 inaugural draft (Round 22, Pick 30, 660th overall Pick). |
| Drafted RF T. Dowd in the 2010 inaugural draft (Round 23, Pick 1, 661st overall Pick). |
| Drafted SP L. Cadore in the 2010 inaugural draft (Round 24, Pick 30, 720th overall Pick). |
| Drafted SP G. Mogridge in the 2010 inaugural draft (Round 25, Pick 1, 721st overall Pick). |
| Drafted SP T. John in the 2010 inaugural draft (Round 26, Pick 30, 780th overall Pick). |
| Drafted RF S. Evans in the 2010 inaugural draft (Round 27, Pick 1, 781st overall Pick). |
| Drafted 1B C. Grimm in the 2010 inaugural draft (Round 28, Pick 30, 840th overall Pick). |
| Drafted 2B R. Sandberg in the 2010 inaugural draft (Round 29, Pick 1, 841st overall Pick). |
| Drafted LF Z. Wheat in the 2010 inaugural draft (Round 30, Pick 30, 900th overall Pick). |
| Drafted MR F. Lacorte in the 2010 inaugural draft (Round 31, Pick 1, 901st overall Pick). |
| Drafted SS A. Dark in the 2010 inaugural draft (Round 32, Pick 30, 960th overall Pick). |
| Drafted CF R. Thomas in the 2010 inaugural draft (Round 33, Pick 1, 961st overall Pick). |
| Drafted CL J. Wetteland in the 2010 inaugural draft (Round 34, Pick 30, 1020th overall Pick). |
| Drafted C J. Roseboro in the 2010 inaugural draft (Round 35, Pick 1, 1021st overall Pick). |
| Drafted 3B L. Gardner in the 2010 inaugural draft (Round 36, Pick 30, 1080th overall Pick). |
| Drafted MR S. Lyle in the 2010 inaugural draft (Round 37, Pick 1, 1081st overall Pick). |
| Drafted CL J. Konstanty in the 2010 inaugural draft (Round 38, Pick 30, 1140th overall Pick). |
| Drafted MR B. Donnelly in the 2010 inaugural draft (Round 39, Pick 1, 1141st overall Pick). |
| Drafted RF L. Piniella in the 2010 inaugural draft (Round 40, Pick 30, 1200th overall Pick). |
| Drafted SS L. Aparicio in the 2010 inaugural draft (Round 41, Pick 1, 1201st overall Pick). |
| Purchased the contract of CL J. Wetteland from Triple A Owensboro. |
| Purchased the contract of MR S. Lyle from Triple A Owensboro. |
| Purchased the contract of 2B R. Sandberg from Triple A Owensboro. |
| Purchased the contract of LF Z. Wheat from Triple A Owensboro. |
| Purchased the contract of RF S. Evans from Triple A Owensboro. |
| Demoted MR E. Smith to Triple A Owensboro. |
| Demoted SP P. Splittorff to Triple A Owensboro. |
| Demoted 1B R. Carew to Triple A Owensboro. |
| Demoted RF T. Dowd to Triple A Owensboro. |
| Demoted 1B W. Dropo to Triple A Owensboro. |
| Demoted C J. Roseboro from Triple A Owensboro to Double A Lexington. |
