| Friday, January 1st, 2010 |
| Drafted 3B J. Foxx in the 2010 inaugural draft (Round 1, Pick 13, 13th overall Pick). |
| Drafted 1B G. Sisler in the 2010 inaugural draft (Round 2, Pick 18, 48th overall Pick). |
| Drafted RF A. Kaline in the 2010 inaugural draft (Round 3, Pick 13, 73rd overall Pick). |
| Drafted SP J. Williams in the 2010 inaugural draft (Round 4, Pick 18, 108th overall Pick). |
| Drafted SP E. Cicotte in the 2010 inaugural draft (Round 5, Pick 13, 133rd overall Pick). |
| Drafted C E. Bailey in the 2010 inaugural draft (Round 6, Pick 18, 168th overall Pick). |
| Drafted SP L. Richmond in the 2010 inaugural draft (Round 7, Pick 13, 193rd overall Pick). |
| Drafted 2B C. Knoblauch in the 2010 inaugural draft (Round 8, Pick 18, 228th overall Pick). |
| Drafted CF H. Wilson in the 2010 inaugural draft (Round 9, Pick 13, 253rd overall Pick). |
| Drafted MR J. Scott in the 2010 inaugural draft (Round 10, Pick 18, 288th overall Pick). |
| Drafted LF W. Berger in the 2010 inaugural draft (Round 11, Pick 13, 313rd overall Pick). |
| Drafted SS D. Force in the 2010 inaugural draft (Round 12, Pick 18, 348th overall Pick). |
| Drafted MR R. Guidry in the 2010 inaugural draft (Round 13, Pick 13, 373rd overall Pick). |
| Drafted SP J. Sambito in the 2010 inaugural draft (Round 14, Pick 18, 408th overall Pick). |
| Drafted MR E. Sosa in the 2010 inaugural draft (Round 15, Pick 13, 433rd overall Pick). |
| Drafted SP J. Magrane in the 2010 inaugural draft (Round 16, Pick 18, 468th overall Pick). |
| Drafted MR S. Radinsky in the 2010 inaugural draft (Round 17, Pick 13, 493rd overall Pick). |
| Drafted MR M. Queen in the 2010 inaugural draft (Round 18, Pick 18, 528th overall Pick). |
| Drafted C D. Daulton in the 2010 inaugural draft (Round 19, Pick 13, 553rd overall Pick). |
| Drafted RF S. Fisher in the 2010 inaugural draft (Round 20, Pick 18, 588th overall Pick). |
| Drafted CF B. McCosky in the 2010 inaugural draft (Round 21, Pick 13, 613rd overall Pick). |
| Drafted LF M. Rettenmund in the 2010 inaugural draft (Round 22, Pick 18, 648th overall Pick). |
| Drafted RF J. Heath in the 2010 inaugural draft (Round 23, Pick 13, 673rd overall Pick). |
| Drafted SP J. Bouton in the 2010 inaugural draft (Round 24, Pick 18, 708th overall Pick). |
| Drafted SP R. Fisher in the 2010 inaugural draft (Round 25, Pick 13, 733rd overall Pick). |
| Drafted RF K. Griffey, Sr. in the 2010 inaugural draft (Round 26, Pick 18, 768th overall Pick). |
| Drafted 3B J. Collins in the 2010 inaugural draft (Round 27, Pick 13, 793rd overall Pick). |
| Drafted CL K. Tekulve in the 2010 inaugural draft (Round 28, Pick 18, 828th overall Pick). |
| Drafted SS J. Glasscock in the 2010 inaugural draft (Round 29, Pick 13, 853rd overall Pick). |
| Drafted 1B H. Walker in the 2010 inaugural draft (Round 30, Pick 18, 888th overall Pick). |
| Drafted 2B F. Vina in the 2010 inaugural draft (Round 31, Pick 13, 913rd overall Pick). |
| Drafted SP M. Mussina in the 2010 inaugural draft (Round 32, Pick 18, 948th overall Pick). |
| Drafted LF D. Mitchell in the 2010 inaugural draft (Round 33, Pick 13, 973rd overall Pick). |
| Drafted CL T. Lewis in the 2010 inaugural draft (Round 34, Pick 18, 1008th overall Pick). |
| Drafted CF M. Alou in the 2010 inaugural draft (Round 35, Pick 13, 1033rd overall Pick). |
| Drafted C H. Gowdy in the 2010 inaugural draft (Round 36, Pick 18, 1068th overall Pick). |
| Drafted SP J. Matlack in the 2010 inaugural draft (Round 37, Pick 13, 1093rd overall Pick). |
| Drafted MR S. Smith in the 2010 inaugural draft (Round 38, Pick 18, 1128th overall Pick). |
| Drafted CL R. Face in the 2010 inaugural draft (Round 39, Pick 13, 1153rd overall Pick). |
| Drafted 2B M. Huggins in the 2010 inaugural draft (Round 40, Pick 18, 1188th overall Pick). |
| Purchased the contract of CL K. Tekulve from Triple A GHosts of '84. |
| Purchased the contract of CL R. Face from Triple A GHosts of '84. |
| Purchased the contract of CL T. Lewis from Triple A GHosts of '84. |
| Purchased the contract of 3B J. Collins from Triple A GHosts of '84. |
| Purchased the contract of SS J. Glasscock from Triple A GHosts of '84. |
| Purchased the contract of CF H. Walker from Triple A GHosts of '84. |
| Demoted SP J. Bouton to Triple A GHosts of '84. |
| Demoted MR M. Queen to Triple A GHosts of '84. |
| Demoted MR S. Radinsky to Triple A GHosts of '84. |
| Demoted LF M. Rettenmund to Triple A GHosts of '84. |
| Demoted LF W. Berger to Triple A GHosts of '84. |
| Demoted CF B. McCosky to Triple A GHosts of '84. |
