| Friday, January 1st, 2010 |
| Drafted CF B. Lange in the 2010 inaugural draft (Round 1, Pick 25, 25th overall Pick). |
| Drafted 2B R. Hornsby in the 2010 inaugural draft (Round 2, Pick 6, 36th overall Pick). |
| Drafted LF T. Conigliaro in the 2010 inaugural draft (Round 3, Pick 25, 85th overall Pick). |
| Drafted SP B. Gibson in the 2010 inaugural draft (Round 4, Pick 6, 96th overall Pick). |
| Drafted SP C. Radbourn in the 2010 inaugural draft (Round 5, Pick 25, 145th overall Pick). |
| Drafted 3B B. Horner in the 2010 inaugural draft (Round 6, Pick 6, 156th overall Pick). |
| Drafted SP G. Maddux in the 2010 inaugural draft (Round 7, Pick 25, 205th overall Pick). |
| Drafted RF S. Sosa in the 2010 inaugural draft (Round 8, Pick 6, 216th overall Pick). |
| Drafted 1B W. McCovey in the 2010 inaugural draft (Round 9, Pick 25, 265th overall Pick). |
| Drafted SP W. Cooper in the 2010 inaugural draft (Round 10, Pick 6, 276th overall Pick). |
| Drafted MR D. Ellsworth in the 2010 inaugural draft (Round 11, Pick 25, 325th overall Pick). |
| Drafted SP R. Ames in the 2010 inaugural draft (Round 12, Pick 6, 336th overall Pick). |
| Drafted MR P. Perez in the 2010 inaugural draft (Round 13, Pick 25, 385th overall Pick). |
| Drafted SS A. Trammell in the 2010 inaugural draft (Round 14, Pick 6, 396th overall Pick). |
| Drafted MR E. Killian in the 2010 inaugural draft (Round 15, Pick 25, 445th overall Pick). |
| Drafted C F. Chance in the 2010 inaugural draft (Round 16, Pick 6, 456th overall Pick). |
| Drafted MR B. Feller in the 2010 inaugural draft (Round 17, Pick 25, 505th overall Pick). |
| Drafted C D. Dietz in the 2010 inaugural draft (Round 18, Pick 6, 516th overall Pick). |
| Drafted MR M. Davis in the 2010 inaugural draft (Round 19, Pick 25, 565th overall Pick). |
| Drafted LF C. Hafey in the 2010 inaugural draft (Round 20, Pick 6, 576th overall Pick). |
| Drafted LF D. Justice in the 2010 inaugural draft (Round 21, Pick 25, 625th overall Pick). |
| Drafted RF M. Alou in the 2010 inaugural draft (Round 22, Pick 6, 636th overall Pick). |
| Drafted LF A. Pafko in the 2010 inaugural draft (Round 23, Pick 25, 685th overall Pick). |
| Drafted SP A. Hammaker in the 2010 inaugural draft (Round 24, Pick 6, 696th overall Pick). |
| Drafted 3B J. Dugan in the 2010 inaugural draft (Round 25, Pick 25, 745th overall Pick). |
| Drafted LF G. Stone in the 2010 inaugural draft (Round 26, Pick 6, 756th overall Pick). |
| Drafted 1B R. Collins in the 2010 inaugural draft (Round 27, Pick 25, 805th overall Pick). |
| Drafted SP S. Barber in the 2010 inaugural draft (Round 28, Pick 6, 816th overall Pick). |
| Drafted RF R. Cullenbine in the 2010 inaugural draft (Round 29, Pick 25, 865th overall Pick). |
| Drafted SS B. Shindle in the 2010 inaugural draft (Round 30, Pick 6, 876th overall Pick). |
| Drafted CF T. Douthit in the 2010 inaugural draft (Round 31, Pick 25, 925th overall Pick). |
| Drafted 3B H. Steinfeldt in the 2010 inaugural draft (Round 32, Pick 6, 936th overall Pick). |
| Drafted 2B B. Avila in the 2010 inaugural draft (Round 33, Pick 25, 985th overall Pick). |
| Drafted MR D. Ruether in the 2010 inaugural draft (Round 34, Pick 6, 996th overall Pick). |
| Drafted MR D. Ellis in the 2010 inaugural draft (Round 35, Pick 25, 1045th overall Pick). |
| Drafted C A. Ashby in the 2010 inaugural draft (Round 36, Pick 6, 1056th overall Pick). |
| Drafted SP H. McCormick in the 2010 inaugural draft (Round 37, Pick 25, 1105th overall Pick). |
| Drafted CL A. Adams in the 2010 inaugural draft (Round 38, Pick 6, 1116th overall Pick). |
| Drafted SS D. Groat in the 2010 inaugural draft (Round 39, Pick 25, 1165th overall Pick). |
| Drafted LF G. Woodling in the 2010 inaugural draft (Round 40, Pick 6, 1176th overall Pick). |
| Purchased the contract of MR D. Ruether from Triple A Round Rock. |
| Purchased the contract of CL A. Adams from Triple A Round Rock. |
| Purchased the contract of SP S. Barber from Triple A Round Rock. |
| Purchased the contract of 3B B. Shindle from Triple A Round Rock. |
| Purchased the contract of 1B R. Collins from Triple A Round Rock. |
| Purchased the contract of 2B B. Avila from Triple A Round Rock. |
| Demoted SP A. Hammaker to Triple A Round Rock. |
| Demoted MR M. Davis to Triple A Round Rock. |
| Demoted 3B B. Horner to Triple A Round Rock. |
| Demoted RF M. Alou to Triple A Round Rock. |
| Demoted LF T. Conigliaro to Triple A Round Rock. |
| Demoted 3B J. Dugan to Double A Corpus Christi. |
