| Friday, January 1st, 2010 |
| Drafted C M. Piazza in the 2010 inaugural draft (Round 1, Pick 30, 30th overall Pick). |
| Drafted LF B. Herman in the 2010 inaugural draft (Round 2, Pick 22, 52nd overall Pick). |
| Drafted CF S. Musial in the 2010 inaugural draft (Round 3, Pick 9, 69th overall Pick). |
| Drafted SP G. Braxton in the 2010 inaugural draft (Round 4, Pick 22, 112nd overall Pick). |
| Drafted SP R. Caldwell in the 2010 inaugural draft (Round 5, Pick 9, 129th overall Pick). |
| Drafted RF J. Gonzalez in the 2010 inaugural draft (Round 6, Pick 22, 172nd overall Pick). |
| Drafted SP B. Holland in the 2010 inaugural draft (Round 7, Pick 9, 189th overall Pick). |
| Drafted SP S. Koufax in the 2010 inaugural draft (Round 8, Pick 22, 232nd overall Pick). |
| Drafted 2B K. Kelly in the 2010 inaugural draft (Round 9, Pick 9, 249th overall Pick). |
| Drafted 1B C. Hickman in the 2010 inaugural draft (Round 10, Pick 22, 292nd overall Pick). |
| Drafted MR B. Shawkey in the 2010 inaugural draft (Round 11, Pick 9, 309th overall Pick). |
| Drafted 3B P. Higgins in the 2010 inaugural draft (Round 12, Pick 22, 352nd overall Pick). |
| Drafted SS L. Appling in the 2010 inaugural draft (Round 13, Pick 9, 369th overall Pick). |
| Drafted MR H. Howell in the 2010 inaugural draft (Round 14, Pick 22, 412nd overall Pick). |
| Drafted SP H. Smith in the 2010 inaugural draft (Round 15, Pick 9, 429th overall Pick). |
| Drafted MR S. Perry in the 2010 inaugural draft (Round 16, Pick 22, 472nd overall Pick). |
| Drafted MR H. Reniff in the 2010 inaugural draft (Round 17, Pick 9, 489th overall Pick). |
| Drafted CL D. Hyde in the 2010 inaugural draft (Round 18, Pick 22, 532nd overall Pick). |
| Drafted C F. Pytlak in the 2010 inaugural draft (Round 19, Pick 9, 549th overall Pick). |
| Drafted DH R. Jefferson in the 2010 inaugural draft (Round 20, Pick 22, 592nd overall Pick). |
| Drafted RF C. Yastrzemski in the 2010 inaugural draft (Round 21, Pick 9, 609th overall Pick). |
| Drafted RF P. Fox in the 2010 inaugural draft (Round 22, Pick 22, 652nd overall Pick). |
| Drafted SS J. Harris in the 2010 inaugural draft (Round 23, Pick 9, 669th overall Pick). |
| Drafted SS V. Castilla in the 2010 inaugural draft (Round 24, Pick 22, 712nd overall Pick). |
| Drafted 2B B. Herman in the 2010 inaugural draft (Round 25, Pick 9, 729th overall Pick). |
| Drafted SP W. McDonald in the 2010 inaugural draft (Round 26, Pick 1, 751st overall Pick). |
| Drafted CL M. Williams in the 2010 inaugural draft (Round 27, Pick 30, 810th overall Pick). |
| Drafted C B. Harper in the 2010 inaugural draft (Round 28, Pick 1, 811st overall Pick). |
| Drafted RF D. Murphy in the 2010 inaugural draft (Round 29, Pick 30, 870th overall Pick). |
| Drafted 1B D. Evans in the 2010 inaugural draft (Round 30, Pick 1, 871st overall Pick). |
| Drafted SP B. Hooton in the 2010 inaugural draft (Round 31, Pick 30, 930th overall Pick). |
| Drafted 3B B. Chapman in the 2010 inaugural draft (Round 32, Pick 1, 931st overall Pick). |
| Drafted 2B B. Myer in the 2010 inaugural draft (Round 33, Pick 30, 990th overall Pick). |
| Drafted LF A. Johnson in the 2010 inaugural draft (Round 34, Pick 1, 991st overall Pick). |
| Drafted SS L. Lary in the 2010 inaugural draft (Round 35, Pick 30, 1050th overall Pick). |
| Drafted CF J. Northrup in the 2010 inaugural draft (Round 36, Pick 1, 1051st overall Pick). |
| Drafted MR A. Holland in the 2010 inaugural draft (Round 37, Pick 30, 1110th overall Pick). |
| Drafted CL H. Woodeshick in the 2010 inaugural draft (Round 38, Pick 1, 1111st overall Pick). |
| Drafted LF F. Howard in the 2010 inaugural draft (Round 39, Pick 30, 1170th overall Pick). |
| Drafted SS W. Barbare in the 2010 inaugural draft (Round 40, Pick 1, 1171st overall Pick). |
| Purchased the contract of CL H. Woodeshick from Triple A Paradise. |
| Purchased the contract of SP B. Hooton from Triple A Paradise. |
| Purchased the contract of RF D. Evans from Triple A Paradise. |
| Purchased the contract of RF D. Murphy from Triple A Paradise. |
| Purchased the contract of 2B B. Myer from Triple A Paradise. |
| Demoted 2B B. Herman to Triple A Paradise. |
| Demoted RF P. Fox to Triple A Paradise. |
| Demoted DH R. Jefferson to Triple A Paradise. |
| Demoted 3B P. Higgins to Triple A Paradise. |
| Demoted 1B C. Hickman to Triple A Paradise. |
| Demoted SS W. Barbare from Triple A Paradise to Double A Tucson. |
| Demoted LF A. Johnson from Triple A Paradise to Double A Tucson. |
