| Friday, January 1st, 2010 |
| Drafted 1B L. Gehrig in the 2010 inaugural draft (Round 1, Pick 11, 11th overall Pick). |
| Drafted CF B. Higginson in the 2010 inaugural draft (Round 2, Pick 20, 50th overall Pick). |
| Drafted RF A. Kaline in the 2010 inaugural draft (Round 3, Pick 11, 71st overall Pick). |
| Drafted SP R. Waddell in the 2010 inaugural draft (Round 4, Pick 20, 110th overall Pick). |
| Drafted SP G. Bradley in the 2010 inaugural draft (Round 5, Pick 11, 131st overall Pick). |
| Drafted SS H. Jennings in the 2010 inaugural draft (Round 6, Pick 20, 170th overall Pick). |
| Drafted SP R. Collins in the 2010 inaugural draft (Round 7, Pick 11, 191st overall Pick). |
| Drafted C J. Lopez in the 2010 inaugural draft (Round 8, Pick 20, 230th overall Pick). |
| Drafted CL W. Hernandez in the 2010 inaugural draft (Round 9, Pick 11, 251st overall Pick). |
| Drafted 3B B. Barrett in the 2010 inaugural draft (Round 10, Pick 20, 290th overall Pick). |
| Drafted MR J. Scott in the 2010 inaugural draft (Round 11, Pick 11, 311st overall Pick). |
| Drafted SP N. Maddox in the 2010 inaugural draft (Round 12, Pick 20, 350th overall Pick). |
| Drafted 2B R. Sandberg in the 2010 inaugural draft (Round 13, Pick 11, 371st overall Pick). |
| Drafted LF R. Carty in the 2010 inaugural draft (Round 14, Pick 20, 410th overall Pick). |
| Drafted SP P. Galvin in the 2010 inaugural draft (Round 15, Pick 11, 431st overall Pick). |
| Drafted MR J. Dilauro in the 2010 inaugural draft (Round 16, Pick 20, 470th overall Pick). |
| Drafted MR T. Stoddard in the 2010 inaugural draft (Round 17, Pick 11, 491st overall Pick). |
| Drafted MR M. Davis in the 2010 inaugural draft (Round 18, Pick 20, 530th overall Pick). |
| Drafted C J. Gooch in the 2010 inaugural draft (Round 19, Pick 11, 551st overall Pick). |
| Drafted 1B J. Fournier in the 2010 inaugural draft (Round 20, Pick 20, 590th overall Pick). |
| Drafted RF O. Gamble in the 2010 inaugural draft (Round 21, Pick 11, 611st overall Pick). |
| Drafted RF D. Murphy in the 2010 inaugural draft (Round 22, Pick 20, 650th overall Pick). |
| Drafted RF J. Heath in the 2010 inaugural draft (Round 23, Pick 11, 671st overall Pick). |
| Drafted 3B M. Dihigo in the 2010 inaugural draft (Round 24, Pick 20, 710th overall Pick). |
| Drafted SP A. Rusie in the 2010 inaugural draft (Round 25, Pick 11, 731st overall Pick). |
| Drafted SP K. Sanders in the 2010 inaugural draft (Round 26, Pick 20, 770th overall Pick). |
| Drafted SP J. Candelaria in the 2010 inaugural draft (Round 27, Pick 11, 791st overall Pick). |
| Drafted LF R. Blades in the 2010 inaugural draft (Round 28, Pick 20, 830th overall Pick). |
| Drafted MR M. Grissom in the 2010 inaugural draft (Round 29, Pick 11, 851st overall Pick). |
| Drafted SP H. Coveleski in the 2010 inaugural draft (Round 30, Pick 20, 890th overall Pick). |
| Drafted CF J. Northrup in the 2010 inaugural draft (Round 31, Pick 11, 911st overall Pick). |
| Drafted 3B A. Devlin in the 2010 inaugural draft (Round 32, Pick 20, 950th overall Pick). |
| Drafted SP J. Vander Meer in the 2010 inaugural draft (Round 33, Pick 11, 971st overall Pick). |
| Drafted SP B. Hooton in the 2010 inaugural draft (Round 34, Pick 20, 1010th overall Pick). |
| Drafted SS D. Bancroft in the 2010 inaugural draft (Round 35, Pick 11, 1031st overall Pick). |
| Drafted 2B B. Grich in the 2010 inaugural draft (Round 36, Pick 20, 1070th overall Pick). |
| Drafted RF B. Bell in the 2010 inaugural draft (Round 37, Pick 11, 1091st overall Pick). |
| Drafted CL D. Knowles in the 2010 inaugural draft (Round 38, Pick 20, 1130th overall Pick). |
| Drafted C H. Gowdy in the 2010 inaugural draft (Round 39, Pick 11, 1151st overall Pick). |
| Drafted 2B W. Randolph in the 2010 inaugural draft (Round 40, Pick 20, 1190th overall Pick). |
