| Friday, January 1st, 2010 |
| Drafted CF W. Mays in the 2010 inaugural draft (Round 1, Pick 8, 8th overall Pick). |
| Drafted 2B H. Trosky in the 2010 inaugural draft (Round 2, Pick 23, 53rd overall Pick). |
| Drafted RF A. Kaline in the 2010 inaugural draft (Round 3, Pick 8, 68th overall Pick). |
| Drafted SP H. Krause in the 2010 inaugural draft (Round 4, Pick 23, 113rd overall Pick). |
| Drafted SP E. Seward in the 2010 inaugural draft (Round 5, Pick 8, 128th overall Pick). |
| Drafted MR B. Blyleven in the 2010 inaugural draft (Round 6, Pick 23, 173rd overall Pick). |
| Drafted SP E. Reulbach in the 2010 inaugural draft (Round 7, Pick 8, 188th overall Pick). |
| Drafted SS A. Rosen in the 2010 inaugural draft (Round 8, Pick 23, 233rd overall Pick). |
| Drafted SP B. Raymond in the 2010 inaugural draft (Round 9, Pick 8, 248th overall Pick). |
| Drafted 3B B. Barrett in the 2010 inaugural draft (Round 10, Pick 23, 293rd overall Pick). |
| Drafted SP E. Shore in the 2010 inaugural draft (Round 11, Pick 8, 308th overall Pick). |
| Drafted 1B E. Murray in the 2010 inaugural draft (Round 12, Pick 23, 353rd overall Pick). |
| Drafted C C. Johnson in the 2010 inaugural draft (Round 13, Pick 8, 368th overall Pick). |
| Drafted MR V. Gregg in the 2010 inaugural draft (Round 14, Pick 23, 413rd overall Pick). |
| Drafted LF R. Carty in the 2010 inaugural draft (Round 15, Pick 8, 428th overall Pick). |
| Drafted MR C. Kerfeld in the 2010 inaugural draft (Round 16, Pick 23, 473rd overall Pick). |
| Drafted MR M. Rojas in the 2010 inaugural draft (Round 17, Pick 8, 488th overall Pick). |
| Drafted C T. Simmons in the 2010 inaugural draft (Round 18, Pick 23, 533rd overall Pick). |
| Drafted MR G. Bearden in the 2010 inaugural draft (Round 19, Pick 8, 548th overall Pick). |
| Drafted LF S. Kemp in the 2010 inaugural draft (Round 20, Pick 23, 593rd overall Pick). |
| Drafted RF J. Cassidy in the 2010 inaugural draft (Round 21, Pick 8, 608th overall Pick). |
| Drafted 1B W. Dropo in the 2010 inaugural draft (Round 22, Pick 23, 653rd overall Pick). |
| Drafted 1B E. Morgan in the 2010 inaugural draft (Round 23, Pick 8, 668th overall Pick). |
| Drafted RF F. Demaree in the 2010 inaugural draft (Round 24, Pick 23, 713rd overall Pick). |
| Drafted 2B R. Youngs in the 2010 inaugural draft (Round 25, Pick 8, 728th overall Pick). |
| Drafted 1B A. Davis in the 2010 inaugural draft (Round 26, Pick 23, 773rd overall Pick). |
| Drafted 2B L. Whitaker in the 2010 inaugural draft (Round 27, Pick 8, 788th overall Pick). |
| Drafted LF J. Cunningham in the 2010 inaugural draft (Round 28, Pick 23, 833rd overall Pick). |
| Drafted CF T. McCarthy in the 2010 inaugural draft (Round 29, Pick 8, 848th overall Pick). |
| Drafted MR B. Miller in the 2010 inaugural draft (Round 30, Pick 23, 893rd overall Pick). |
| Drafted SS C. Tierney in the 2010 inaugural draft (Round 31, Pick 8, 908th overall Pick). |
| Drafted MR M. Wohlers in the 2010 inaugural draft (Round 32, Pick 23, 953rd overall Pick). |
| Drafted 3B T. Fryman in the 2010 inaugural draft (Round 33, Pick 8, 968th overall Pick). |
| Drafted MR B. Dawley in the 2010 inaugural draft (Round 34, Pick 23, 1013rd overall Pick). |
| Drafted MR B. Thigpen in the 2010 inaugural draft (Round 35, Pick 8, 1028th overall Pick). |
| Drafted CL K. Foulke in the 2010 inaugural draft (Round 36, Pick 23, 1073rd overall Pick). |
| Drafted C A. Ashby in the 2010 inaugural draft (Round 37, Pick 8, 1088th overall Pick). |
| Drafted SP R. Faber in the 2010 inaugural draft (Round 38, Pick 23, 1133rd overall Pick). |
| Drafted RF E. Webb in the 2010 inaugural draft (Round 39, Pick 8, 1148th overall Pick). |
| Drafted 1B A. Oliver in the 2010 inaugural draft (Round 40, Pick 23, 1193rd overall Pick). |
