| Friday, January 1st, 2010 |
| Drafted 1B F. Thomas in the 2010 inaugural draft (Round 1, Pick 4, 4th overall Pick). |
| Drafted LF T. Conigliaro in the 2010 inaugural draft (Round 2, Pick 27, 57th overall Pick). |
| Drafted RF A. Kaline in the 2010 inaugural draft (Round 3, Pick 4, 64th overall Pick). |
| Drafted SP P. Werden in the 2010 inaugural draft (Round 4, Pick 27, 117th overall Pick). |
| Drafted SP B. Rhines in the 2010 inaugural draft (Round 5, Pick 4, 124th overall Pick). |
| Drafted SS W. English in the 2010 inaugural draft (Round 6, Pick 27, 177th overall Pick). |
| Drafted SP B. Caruthers in the 2010 inaugural draft (Round 7, Pick 4, 184th overall Pick). |
| Drafted C B. Dickey in the 2010 inaugural draft (Round 8, Pick 27, 237th overall Pick). |
| Drafted 3B K. Caminiti in the 2010 inaugural draft (Round 9, Pick 4, 244th overall Pick). |
| Drafted 2B L. Doyle in the 2010 inaugural draft (Round 10, Pick 27, 297th overall Pick). |
| Drafted CL J. Borden in the 2010 inaugural draft (Round 11, Pick 4, 304th overall Pick). |
| Drafted MR H. Eller in the 2010 inaugural draft (Round 12, Pick 27, 357th overall Pick). |
| Drafted MR R. Marquard in the 2010 inaugural draft (Round 13, Pick 4, 364th overall Pick). |
| Drafted MR A. McBean in the 2010 inaugural draft (Round 14, Pick 27, 417th overall Pick). |
| Drafted SP N. Callahan in the 2010 inaugural draft (Round 15, Pick 4, 424th overall Pick). |
| Drafted SP M. Fidrych in the 2010 inaugural draft (Round 16, Pick 27, 477th overall Pick). |
| Drafted CF S. Chapman in the 2010 inaugural draft (Round 17, Pick 4, 484th overall Pick). |
| Drafted C S. Alomar, Jr. in the 2010 inaugural draft (Round 18, Pick 27, 537th overall Pick). |
| Drafted RF J. Rice in the 2010 inaugural draft (Round 19, Pick 4, 544th overall Pick). |
| Drafted 1B C. McVey in the 2010 inaugural draft (Round 20, Pick 27, 597th overall Pick). |
| Drafted 1B D. Brouthers in the 2010 inaugural draft (Round 21, Pick 4, 604th overall Pick). |
| Drafted RF D. Murphy in the 2010 inaugural draft (Round 22, Pick 27, 657th overall Pick). |
| Drafted SS J. Sullivan in the 2010 inaugural draft (Round 23, Pick 4, 664th overall Pick). |
| Drafted 3B J. Dugan in the 2010 inaugural draft (Round 24, Pick 27, 717th overall Pick). |
| Drafted RF B. Southworth in the 2010 inaugural draft (Round 25, Pick 4, 724th overall Pick). |
