| Friday, January 1st, 2010 |
| Drafted LF O. Charleston in the 2010 inaugural draft (Round 1, Pick 21, 21st overall Pick). |
| Drafted RF J. Jackson in the 2010 inaugural draft (Round 2, Pick 10, 40th overall Pick). |
| Drafted 3B B. Horner in the 2010 inaugural draft (Round 3, Pick 21, 81st overall Pick). |
| Drafted SP F. Schupp in the 2010 inaugural draft (Round 4, Pick 10, 100th overall Pick). |
| Drafted SP S. King in the 2010 inaugural draft (Round 5, Pick 21, 141st overall Pick). |
| Drafted MR B. Blyleven in the 2010 inaugural draft (Round 6, Pick 10, 160th overall Pick). |
| Drafted CF H. Mueller in the 2010 inaugural draft (Round 7, Pick 21, 201st overall Pick). |
| Drafted C B. Dickey in the 2010 inaugural draft (Round 8, Pick 10, 220th overall Pick). |
| Drafted SP B. Foster in the 2010 inaugural draft (Round 9, Pick 21, 261st overall Pick). |
| Drafted SS J. Reilly in the 2010 inaugural draft (Round 10, Pick 10, 280th overall Pick). |
| Drafted 2B R. Mack in the 2010 inaugural draft (Round 11, Pick 21, 321st overall Pick). |
| Drafted 1B M. Epstein in the 2010 inaugural draft (Round 12, Pick 10, 340th overall Pick). |
| Drafted MR J. Orosco in the 2010 inaugural draft (Round 13, Pick 21, 381st overall Pick). |
| Drafted MR V. Gregg in the 2010 inaugural draft (Round 14, Pick 10, 400th overall Pick). |
| Drafted SP D. Brown in the 2010 inaugural draft (Round 15, Pick 21, 441st overall Pick). |
| Drafted SP M. Fidrych in the 2010 inaugural draft (Round 16, Pick 10, 460th overall Pick). |
| Drafted MR H. Reniff in the 2010 inaugural draft (Round 17, Pick 21, 501st overall Pick). |
| Drafted C M. Cochrane in the 2010 inaugural draft (Round 18, Pick 10, 520th overall Pick). |
| Drafted LF S. Kemp in the 2010 inaugural draft (Round 19, Pick 21, 561st overall Pick). |
| Drafted 1B J. Mayberry in the 2010 inaugural draft (Round 20, Pick 10, 580th overall Pick). |
| Drafted 1B E. Morgan in the 2010 inaugural draft (Round 21, Pick 21, 621st overall Pick). |
| Drafted CF W. Moses in the 2010 inaugural draft (Round 22, Pick 10, 640th overall Pick). |
| Drafted 3B M. Dihigo in the 2010 inaugural draft (Round 23, Pick 21, 681st overall Pick). |
| Drafted 2B R. Youngs in the 2010 inaugural draft (Round 24, Pick 10, 700th overall Pick). |
| Drafted 3B O. Hale in the 2010 inaugural draft (Round 25, Pick 21, 741st overall Pick). |
| Drafted 1B A. Davis in the 2010 inaugural draft (Round 26, Pick 10, 760th overall Pick). |
| Drafted LF R. Blades in the 2010 inaugural draft (Round 27, Pick 21, 801st overall Pick). |
| Drafted SS G. McDougald in the 2010 inaugural draft (Round 28, Pick 10, 820th overall Pick). |
| Drafted CF L. Dykstra in the 2010 inaugural draft (Round 29, Pick 21, 861st overall Pick). |
| Drafted 2B C. Biggio in the 2010 inaugural draft (Round 30, Pick 10, 880th overall Pick). |
| Drafted RF J. Tobin in the 2010 inaugural draft (Round 31, Pick 21, 921st overall Pick). |
| Drafted CL R. Perranoski in the 2010 inaugural draft (Round 32, Pick 10, 940th overall Pick). |
| Drafted 3B H. Carpenter in the 2010 inaugural draft (Round 33, Pick 21, 981st overall Pick). |
| Drafted CL D. Hyde in the 2010 inaugural draft (Round 34, Pick 10, 1000th overall Pick). |
| Drafted C H. Severeid in the 2010 inaugural draft (Round 35, Pick 21, 1041st overall Pick). |
| Drafted CL U. Urbina in the 2010 inaugural draft (Round 36, Pick 10, 1060th overall Pick). |
| Drafted MR B. Dawley in the 2010 inaugural draft (Round 37, Pick 21, 1101st overall Pick). |
| Drafted CL J. Mesa in the 2010 inaugural draft (Round 38, Pick 10, 1120th overall Pick). |
| Drafted CL D. Knowles in the 2010 inaugural draft (Round 39, Pick 21, 1161st overall Pick). |
| Drafted LF E. Slaughter in the 2010 inaugural draft (Round 40, Pick 10, 1180th overall Pick). |
