| Friday, January 1st, 2010 |
| Drafted 3B J. Foxx in the 2010 inaugural draft (Round 1, Pick 13, 13th overall Pick). |
| Drafted C B. Delancey in the 2010 inaugural draft (Round 2, Pick 18, 48th overall Pick). |
| Drafted RF A. Kaline in the 2010 inaugural draft (Round 3, Pick 13, 73rd overall Pick). |
| Drafted SP H. Pollet in the 2010 inaugural draft (Round 4, Pick 18, 108th overall Pick). |
| Drafted SP J. Dygert in the 2010 inaugural draft (Round 5, Pick 13, 133rd overall Pick). |
| Drafted 1B H. Zimmerman in the 2010 inaugural draft (Round 6, Pick 18, 168th overall Pick). |
| Drafted SP H. Gruber in the 2010 inaugural draft (Round 7, Pick 13, 193rd overall Pick). |
| Drafted SP S. Carlton in the 2010 inaugural draft (Round 8, Pick 18, 228th overall Pick). |
| Drafted 2B T. Lazzeri in the 2010 inaugural draft (Round 9, Pick 13, 253rd overall Pick). |
| Drafted SP E. Karger in the 2010 inaugural draft (Round 10, Pick 18, 288th overall Pick). |
| Drafted LF T. Francona in the 2010 inaugural draft (Round 11, Pick 13, 313rd overall Pick). |
| Drafted CF S. Chapman in the 2010 inaugural draft (Round 12, Pick 18, 348th overall Pick). |
| Drafted MR P. Ragan in the 2010 inaugural draft (Round 13, Pick 13, 373rd overall Pick). |
| Drafted SS H. Johnson in the 2010 inaugural draft (Round 14, Pick 18, 408th overall Pick). |
| Drafted CL R. Camp in the 2010 inaugural draft (Round 15, Pick 13, 433rd overall Pick). |
| Drafted CL B. Caudill in the 2010 inaugural draft (Round 16, Pick 18, 468th overall Pick). |
| Drafted MR G. Minton in the 2010 inaugural draft (Round 17, Pick 13, 493rd overall Pick). |
| Drafted MR J. Garvin in the 2010 inaugural draft (Round 18, Pick 18, 528th overall Pick). |
| Drafted C S. Alomar, Jr. in the 2010 inaugural draft (Round 19, Pick 13, 553rd overall Pick). |
| Drafted RF S. Fisher in the 2010 inaugural draft (Round 20, Pick 18, 588th overall Pick). |
| Drafted LF B. Twombly in the 2010 inaugural draft (Round 21, Pick 13, 613rd overall Pick). |
| Drafted CF K. Puckett in the 2010 inaugural draft (Round 22, Pick 18, 648th overall Pick). |
| Drafted 2B R. Hunt in the 2010 inaugural draft (Round 23, Pick 13, 673rd overall Pick). |
| Drafted 3B B. Werber in the 2010 inaugural draft (Round 24, Pick 18, 708th overall Pick). |
| Drafted 3B J. Dugan in the 2010 inaugural draft (Round 25, Pick 13, 733rd overall Pick). |
| Drafted LF C. Jones in the 2010 inaugural draft (Round 26, Pick 18, 768th overall Pick). |
| Drafted RF I. Meusel in the 2010 inaugural draft (Round 27, Pick 13, 793rd overall Pick). |
| Drafted SS C. Galloway in the 2010 inaugural draft (Round 28, Pick 18, 828th overall Pick). |
| Drafted SP W. Spahn in the 2010 inaugural draft (Round 29, Pick 13, 853rd overall Pick). |
| Drafted C C. Sawatski in the 2010 inaugural draft (Round 30, Pick 18, 888th overall Pick). |
| Drafted SP E. Cushman in the 2010 inaugural draft (Round 31, Pick 13, 913rd overall Pick). |
| Drafted SP F. Bradley in the 2010 inaugural draft (Round 32, Pick 18, 948th overall Pick). |
| Drafted CF D. Dimaggio in the 2010 inaugural draft (Round 33, Pick 13, 973rd overall Pick). |
| Drafted 3B H. Groh in the 2010 inaugural draft (Round 34, Pick 18, 1008th overall Pick). |
| Drafted 1B D. Magadan in the 2010 inaugural draft (Round 35, Pick 13, 1033rd overall Pick). |
| Drafted CL W. White in the 2010 inaugural draft (Round 36, Pick 18, 1068th overall Pick). |
| Drafted MR E. Willett in the 2010 inaugural draft (Round 37, Pick 13, 1093rd overall Pick). |
| Drafted MR A. Nehf in the 2010 inaugural draft (Round 38, Pick 18, 1128th overall Pick). |
| Drafted 2B J. Hayes in the 2010 inaugural draft (Round 39, Pick 13, 1153rd overall Pick). |
| Drafted 2B G. Beckert in the 2010 inaugural draft (Round 40, Pick 18, 1188th overall Pick). |
